We have reported that NK cells can specifically recognise cells in mitosis, perhaps using cell division as an indicator for potential danger [Blood. 2007; 109:670-3]. We are currently probing the mechanisms and functions for this.

We have also reported a reciprocal regulation between macrophages and NK cells [Blood. 2007; 109:3776-85]. This interaction may be important in a variety of circumstances including immune responses to malaria [J Immunol. 2005; 175:7466-73, J Immunol. 2003; 171:5396-405].

We have also provided some early evidence for a role of sub-synaptic vesicles in signalling [Sci Signal. 2010;3(121):ra36]. Towards understanding the basis for immune receptors triggering we have also tested the importance of protein size in signal transduction [PLoS Comput Biol. 2011; 7:e1002076; J Immunol. 2011; 187:760-73; Biophys J. 2011;100:2865-74; PLoS One. 2010;5(11):e15374; Front Immunol. 2012; 3:308].

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