While working as a postdoctoral researcher with Jack Strominger at Harvard, we were the first to describe an NK cell immune synapse [PNAS. 1999; 96:15062-7].

My laboratory has since continued to probe functions and mechanisms for the NK cell synapse e.g. J Exp Med. 2001; 194:1507-17, J Exp Med. 2004; 199:1005-10, summarised in Trends Immunol. 2004; 25:323-7 and 2002; 23:356-63 and for a more general audience in Scientific American, 2006; 294:48-55.

We reported microclusters of inhibitory signalling at synapses [J Cell Biol. 2006; 174:153-61] and found that segregation of proteins at synapses can be controlled by their cell surface density [J Immunol. 2006; 177:6904-10].We have investigated the interaction between Nk cells and macrophages [Blood. 2007; 109:3776-85].

Most recently, we have used super-resolution microscopy to probe the nanometre-scale organisation of the NK cell surface and immune synapse [Blood. 2012; 120:3729-40; PLoS Biol. 2011;9:e1001152].

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